Technological and industrial capacity

Pharmaceutical Product Manufacturing Company

Certification according to GMP (Good Manufacturing Practices) Standard

Kubus has a Quality Management System according to GMP or NCF standards certified by the Spanish Medicines Agency.

Certification according to ISO 9001:2015

Kubus has a Quality Management System according to ISO 9001:2015 certified by Bureau Veritas.

Processing Entity for Animal Health Products and Pharmaceutical Products

Kubus is authorized and registered in the Registry of Animal Health Product Manufacturers of the Ministry of Agriculture, Food and Environment under number HCM-085, and in the Medicines Agency under registration number 6678E.

Importer of products for animal feed

Kubus is registered in the Register of Importers of Products for Animal Feed, managed by the Directorate of Agricultural and Livestock Resources, under number 136.

Intermediate Establishment that puts into circulation premixes and animal feed: code I

Kubus has been included within the register of Establishments and Intermediaries authorized with the activity as intermediaries that put into circulation premixes and feeds with the number α ESP-2800043, in the facilities of Madrid, in the Register of the Community of Madrid, General Directorate of Environment.

Establishment registered in the Register of Feed Business Operators of the Autonomous Community of Extremadura as manufacturers for the commercialization of compound feed.

Likewise, Kubus, in its livestock facilities with a feed factory on the Valdelinares Estate, in Olivenza (Badajoz), has authorization for the manufacture and commercialization of compound feed, in which feed additives or premixes containing additives (except coccidiostats, histomonostats and growth promoters) are used. The registration number is ESP-06100153.

R&D strategy

The KUBUS R&D department works tirelessly putting all its efforts in the reproductive progress of our customers. We are working on new formulations of optimized diluents demanded by the most critical sector.
KUBUS is a benchmark in innovation. It understands today’s needs, such as full automation of processes in the insemination center as well as on the farm. KUBUS is committed to technification.

Technological DNA

Kubus is responsible for the manufacture of all its diluents. All these products are classified as animal health products for the hygiene, care and handling of animals, or general veterinary material.
Over the years, the company has been equipping its laboratory to make it one of the most complete private laboratories in Spain for research in the field of reproductive biotechnology.

Some of the techniques that Kubus has been performing over the last years

  • Chemical analysis of purified water and insemination diluents
  • Estimación de la concentración espermática mediante distintas técnicas (cámara de Burker, Nucleocounter, espectrofotómetro, colorímetro)
  • Microbiological control of semen.
  • Basic seminal evaluation by phase contrast microscopy: motility, acrosomia, abnormal forms.
  • Sperm staining: functional and vital tests
  • Sperm Functionality Tests: HOST and ORT
  • Advanced sperm evaluation by fluorescence microscopy: sperm viability by triple stain, viability by Sybr-14
  • Semen cryopreservation
  • Porcine embryo vitrification
  • In vitro fertilization
  • Analysis of pathogens in semen by PCR techniques.

Technological developments carried out by the company. Participation in international R&D&I projects. Publications and patents.

1983
Launch of MR-A® Long Shelf Life Boar Semen Diluent
1986
Foundation of KUBUS. Registration of MR-A as an animal health product
1988
Development of Semen Dialysis Technique
1990
KUBUS expands in Central and South America First Symposium on Porcine Reproduction
1992
KUBUS arrives in North America
1993
Development of hands-free techniqueDevelopment of the first boar management program MR-A® Win Pro, software for the management of artificial insemination centers.
1994
Predil® MR-A, the first synthetic boar seminal plasma is launched, revitalizing and activating semen, increasing fertility.
1995
Duroc breed selection farm
1996
Utility model of Saddlebag for Technical Artificial Insemination Hands-Free Technique
1997
Training services and featured projects for Insemination Centers.
1998
Launch of the artificial insemination extender for rabbits MRAbitConstitution Kubus Inc (USA)
1999
Development and commercialization of a graduated catheter for nulliparous insemination.
2000
KUBUS entry into the Asian marketSingle-farrowing porcine technology development project
2001
Launching of the Caddy for artificial insemination
2002
Launch of MR-A Thaw for use in frozen boar semenAcquisition of the Insemination Center in Seville with capacity for 100 boars.
2003
Deionized water in bag in box
2004
Launch of MR-A 3, medium-holding diluent
2005
Ready-to-use liquid diluent Liquidil Vitesse
2006
Informative video Porcine Sperm Insemination Center Andalusia
2007
Development of fluorescence semen analysis techniques in the Kubus laboratory.
2008
Launch of Iber Fatty Pig Diluter- and ready-to-use diluter Liquidil Vitesse, awarded as innovative product at FIMA GANADERA
2009
Development of Adapboar nutritional adaptor, in the form of cookies.
2010
Manual of artificial insemination (new edition)
2011
Launch of new sealing machine for blisters and tubes at the same time
2012
MR-A® Fox fox semen extender
2013
Launch of artificial insemination product line for dogs
2014
Automatic pick-up colt with disposable artificial vagina
2015
Development of the KUBUS electrotechnical department
2016
Establishment of a branch in China: KUBUS SUZHOU BIOTECHNOLOGY
2017
Launch of QS1000 automated blister packaging machines
2018
KUBUS obtains GMP certification
2019
Development of the new SPERMCARE 88L semen preservation refrigerator
2020
Launching of CASA, automatic semen analysis program, OCSA